Chapter 726 The choice of brain nuclei!
Xu Qiu didn't say anything. She thanked him and packed up with Essette.
A brain pacemaker, also known as a dual-channel implantable deep brain electrical stimulation pulse generator, mainly includes several parts, such as a generator kit, an electrode lead set and an extension lead set.
These three parts have a large number of technical barriers.
Such as the pulse generator of the generator kit, the depth limiter of the electrode lead kit, the electrode tunneling tool, etc.
The various parts of a single part also require extremely precise control and measurement.
Before brain pacemakers, studies had long shown that the accumulation of electrical charges can cause permanent damage to animal nerve cells.
And this has always been the key to why various deep brain stimulation methods have not been favored.
But Xu Qiu dared to do research in this area because he had already found a way to crack it!
As long as symmetrical bipolar stimulation pulses are used, the total charge obtained by the animal's nervous tissue can be zero. In this case, the damage to the nervous tissue can be reduced to a minimum.
Although there has been some damage, compared with the symptoms caused by neurological diseases such as Parkinson's, the damage caused by bipolar stimulation pulses is almost negligible!
Of course, proving that symmetrical bipolar stimulation pulses cause minimal damage is only the beginning.
The traditional bipolar pulse is a positive and negative power supply. The switching speed of the positive and negative poles of the power supply cannot meet the frequency of the positive and negative pulses, which will cause more serious damage to the brain tissue.
If you want to increase the switching speed, you can only use the double-pulse multi-way switch designed by Xu Qiu to control the switching speed at the nanosecond level to meet the standards for clinical application.
only……
The core secret of the double-pulse multi-way switch is now controlled by Xu Qiu, and others have no idea that there is such a core design.
If it weren't for Xu Qiu's god-level scientific research ability and the engineering foundation brought by the automatic craniotomy machine, he would not be able to do all this...
Even so, he experimented many times in the simulated operating room before coming up with the final plan.
"The last point is the choice of the location of the nucleus."
Simply put, it is the area where the brain pacemaker is placed, that is, where it receives electrical stimulation.
The brain has a large number of nuclei. In the brainstem alone, there are seven large nuclei, such as general trunk motor nuclei, special visceral motor nuclei, etc. There are also several small nuclei under the large nuclei, such as general body nuclei.
The motor nuclei include the oculomotor nucleus, trochlear nucleus, abducens nucleus and hypoglossal nucleus...
Which location to choose for the brain pacemaker is related to the difficulty of the surgery on the one hand, and another key point is the body's reaction to the electrical stimulation of this nucleus location.
To put it bluntly, it is a stimulating effect.
Xu Qiu directly contacted the Animal Experiment Department and asked them to send the twelve SPF male rats they had ordered.
Essette was a little surprised: "Doctor Xu, you don't even take a break?"
"Time is of the essence."
"A male rat with SPF level? If you want to do some experiments, I'll help you."
"No, I can do this myself."
Essette paused, picked up a pile of information next to him, flipped through it a few times, and said: "Dr. Xu, are you planning to study brain pacemakers? I see you chose bipolar stimulation pulses. This is academia.
A direction that I have never considered before, you are indeed an all-round genius as the rumors say!"
Xu Qiu nodded noncommittally, thinking in her mind... could the Animal Experiment Department send it quickly? They were still waiting to open the skulls of the rats.
"But I want to remind you that in order to reduce damage to brain tissue, the switching speed of the positive and negative electrodes must be increased, but there is currently no technology that can do this."
Xu Qiu said without hesitation: "It's really difficult to solve."
"Are you going to increase the switching speed, or use other methods to avoid it? I happen to be studying bipolar pulses, and I'm here to help you!" Essette's voice was filled with excitement.
Xu Qiu turned to look at Esset.
This is the person I have interacted with the most at the scientific research base. He is an honest person, a scientific researcher, and is devoted to the project.
For four months, other researchers were unwilling to work overtime, but Essette followed him and worked more than fourteen hours a day, like a desperate man.
Should we continue to study with him as before?
If he is left alone, there is a certain possibility that the bipolar pulse multi-way switch will leak!
Just when Xu Qiu was hesitating, Essette suddenly held Xu Qiu's hand and said in a pleading tone: "As a friend, I want to help you overcome this difficulty! If there is a breakthrough, I might be able to judge this year.
Go to Professor!”
Xu Qiu was startled for a moment.
Compared with other researchers, Aisette has no background. Therefore, although he is very capable and has served as a chief engineer many times, his professional title is still stuck at associate professor.
He was silent for a moment and asked: "Do you want to participate in this project just to evaluate the professor?"
Essette smiled and said: "Of course not, I want to overcome the difficulty of brain pacemakers and allow more patients to receive treatment! This will be good news to patients around the world!"
Xu Qiu also laughed.ωωw..net
He shook his head and said: "Forget it, I only plan to do experiments on SPF male rats. As for the problem of switching speed, I haven't considered it yet. There are still two months, and I still have time."
Essette wanted to say something else, but when she saw that Xu Qiu had already turned her head to read the progress reports of each group, everything she wanted to say was stuck in her throat.
A few hours later, when Xu Qiu entered the animal laboratory alone and closed the door, Essette punched the table and left the experimental building with an angry look on his face.
"Dean, it failed."
Essette dialed Dean Miaoyou's phone number.
He lowered his voice and said, "I don't know why, but Xu Qiu seems to be doubting me."
They prepared this plan for four months.
Other researchers were very indifferent to Xu Qiu. Except for work, they regarded Xu Qiu as a transparent person. On the contrary, Essette acted as if she admired Xu Qiu extremely, and was simple but enthusiastic...
In the beginning, he did gain Xu Qiu's friendship.
But I didn’t expect that everything was an illusion. Xu Qiu didn’t regard him as one of her own!
"He said he hasn't thought of a solution yet?"
Dean Miaoyou thought for a moment and said: "You should continue to hibernate. He is right. There are still two months left and this project will not end so soon."
"Okay, but I suggest you give him more stumbling blocks, and I will step in to smooth things over. This way we can get to know Xu Qiu more quickly!"
"This is too deliberate. If the purpose is too strong, there will be more flaws."
"Yes, then I will continue to contact him according to my previous personality."
After hanging up the phone, Essette looked back at the towering No. 3 Scientific Research Building. He squinted his eyes and his pupils suddenly contracted the next moment.
Outside the animal laboratory on the seventh floor, Xu Qiu was leaning on the balcony railing, looking in his direction, with a faint smile on his face...
——
Chapter completed!